ARMM011P-21 [Monoclonal Antibody]
Phospho-AKT1/2/3 Substrate (RXRXXS*/T*) Rabbit Monoclonal Antibody
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Species:   Rabbit
Applications:   W, E-P
Immunogen Range:   RXRXXS*/T*
Clonality:   Monoclonal Antibody
Isotype:   IgG
GENE ID:   /
Swiss Prot:   /
Synonyms:   /
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Background:   An important class of kinases, referred to as Arg-directed kinases or AGC-family kinases, includes cAMP-dependent protein kinase (PKA), cGMP-dependent protein kinase (PKG), protein kinase C, Akt, and RSK. These kinases share a substrate specificity characterized by Arg at position -3 relative to the phosphorylated Ser or Thr (1,2). Akt plays a central role in mediating critical cellular responses including cell growth and survival, angiogenesis, and transcriptional regulation (3-5). While a number of Akt substrates are known (such as GSK-3, Bad, and caspase-9) many important substrates await discovery. Akt phosphorylates substrates only at Ser/Thr in a conserved motif characterized by Arg at positions -5 and -3 (6).
Caculated MW:   /
Observed MW:   Refer to Figures
Applications:   WB 1:1000
Reacitivity:   All
For research use only. Not intended for diagnostic or therapeutic use!
Additional information