ARP5243-11 [Polyclonal Antibody]
ABCB1 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB ELISA
Immunogen Range:   A synthetic peptide corresponding to amino acids 262-277 of human ABCB1
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   5243
Swiss Prot:   P08183
Synonyms:   ABC20, CD243, CLCS, GP170, MDR1, MGC163296, P-GP, PGY1
Purification:   Affinity purification
Storage:   Store at 4°C. For long term storage store at -20°C in 20 mM KH2PO4, 150 mM NaCl, pH 7.2 (0.01% sodium azide).Avoid freeze/thaw cycles.
Background:   The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq
Caculated MW:   180 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:200-1:2000
Reacitivity:   Dog, Human, Monkey, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information