ARP4261-11 [Polyclonal Antibody]
CIITA Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB
Immunogen Range:   A recombinant Flag fusion protein corresponding to amino acids 1-333 of human CIITA
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   4261
Swiss Prot:   P33076
Synonyms:   C2TA, CIITAIV, MHC2TA, NLRA
Purification:   Affinity purification
Storage:   Store at 4°C. For long term storage store at -20°C in antiserum (0.01% sodium azide).Avoid freeze/thaw cycles.
Background:   This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. [provided by RefSeq
Caculated MW:   140 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:500
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information