ARP545-11 [Polyclonal Antibody]
ATR Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB ELISA
Immunogen Range:   A synthetic peptide corresponding to amino acids 262-277 of human ATR
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   545
Swiss Prot:   Q13535
Synonyms:   FRP1, MEC1, SCKL, SCKL1
Purification:   Affinity purification
Storage:   Store at 4°C. For long term storage store at -20°C in 20 mM KH2PO4, 150 mM NaCl, pH 7.2 (0.01% sodium azide).Avoid freeze/thaw cycles.
Background:   Ataxia telangiectasia mutated kinase (ATM) and ataxia telangiectasia and Rad3-related kinase (ATR) are PI3 kinase-related kinase (PIKK) family members that phosphorylate multiple substrates on serine or threonine residues that are followed by a glutamine in response to DNA damage or replication blocks (1-3). Despite the essential role of ATR in cell cycle signaling and DNA repair processes, little is known about its activation. Phosphorylation of ATR at serine 428 in response to UV-induced DNA damage has been suggested as a means of activating ATR (4,5). Threonine 1989 was also recently identified as a potential marker of activated ATR (6,7).
Caculated MW:   300 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:1000-1:5000
Reacitivity:   Dog, Human, Monkey, Mouse, Rat, Xenopus
For research use only. Not intended for diagnostic or therapeutic use!
Additional information