ARP838-13 [Polyclonal Antibody]
CASP5 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB
Immunogen Range:   A synthetic peptide corresponding to N-terminus of human CASP5
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   838
Swiss Prot:   P51878
Synonyms:   ICE(rel)III, ICEREL-III, ICH-3, MGC141966
Purification:   Affinity purification
Storage:   Store at -20°C in PBS (0.02% sodium azide).Avoid freeze/thaw cycles.
Background:   This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq
Caculated MW:   20,48 kDa
Observed MW:   Refer to Figures
Applications:   WB 1 ug/mL
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information