ARPM003P-11 [Polyclonal Antibody]
Phospho-Ser YWHA Binding Motif Rabbit Polyclonal Antibody
www.yhsbio.com
market@yhsbio.com
support@yhsbio.com
+86-21-54651191
Room 703,Building 6,333# Guiping
Rd.,Xuhui District,Shanghai,China
DATASHEET
Species:   Rabbit
Applications:   WB
Immunogen Range:   A synthetic phosphopeptide corresponding to residues surrounding S58 of rat 14-3-3 protein
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   /
Swiss Prot:   /
Synonyms:   /
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM HEPES, 150 mM NaCl, pH 7.5 (50% glycerol, 10% BSA.Avoid freeze/thaw cycles.
Background:   The 14-3-3 proteins are a highly conserved family of proteins involved in the regulation of cell survival, apoptosis, proliferation and checkpoint control (1-5). Biological regulation by 14-3-3 is mediated through phosphorylation-dependent protein-protein interactions (6). Two different phospho-Ser-containing motifs are found within nearly all known 14-3-3 binding proteins (7). Motif 1 (Arg/Lys and Ser at positions -3 and -2, phospho-Ser at position 0, and Pro at position +2) is found in critical regulatory proteins including Bad, cdc25C, FKHRL1, PKC and c-Raf (5,7). Phospho-(Ser) 14-3-3 Binding Motif Polyclonal and (4E2) Monoclonal Antibodies provide powerful tools for the discovery and characterization of potential 14-3-3 binding proteins containing this motif and for high throughput drug discovery.
Caculated MW:   29 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:1000
Reacitivity:   Bovine, Chiken, Dog, Human, Mouse, Primates, Rat, Sheep, Xenopus, Zebrafish
For research use only. Not intended for diagnostic or therapeutic use!
Additional information