ARP25085P-11 [Polyclonal Antibody]
Phospho-TH-Ser31 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB IHC IF
Immunogen Range:   A synthetic phosphopeptide corresponding to residues surrounding S31 of rat Th
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   25085
Swiss Prot:   P07101
Synonyms:   Th
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM HEPES, 150 mM NaCl, pH 7.5 (50% glycerol, 10% BSA.Avoid freeze/thaw cycles.
Background:   Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the synthesis of the neurotransmitter dopamine and other catecholamines. TH functions as a tetramer, with each subunit composed of a regulatory and catalytic domain, and exists in several different isoforms (1,2). This enzyme is required for embryonic development since TH knockout mice die before or at birth (3). Levels of transcription, translation and posttranslational modification regulate TH activity. The amino-terminal regulatory domain contains three serine residues: Ser9, Ser31 and Ser40. Phosphorylation at Ser40 by PKA positively regulates the catalytic activity of TH (4-6). Phosphorylation at Ser31 by CDK5 also increases the catalytic activity of TH through stabilization of TH protein levels (7-9).
Caculated MW:   60 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:1000
IHC 1:1000
IF 1:1000
Reacitivity:   Mouse, Primates, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information