ARP6464-12 [Polyclonal Antibody]
SHC1 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB
Immunogen Range:   A synthetic peptide corresponding to amino acids 450-474 of human SHC1 and mouse Shc1
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   6464
Swiss Prot:   P29353
Synonyms:   FLJ26504, SHC, SHCA
Purification:   Affinity purification
Storage:   Store at -20°C in buffer containing 0.02% sodium azide.Avoid freeze/thaw cycles.
Background:   Shc possesses SH2 and PTB domains and serves as a scaffold protein in signaling for a variety of receptor tyrosine kinases. Shc exists in p46, p52 and p66 isoforms, which are produced by using alternative translation initiation sites or a differentially spliced message (1-3). In response to extracellular signals, the SH2 and PTB domains of Shc interact with the activated receptors, leading to phosphorylation of Shc on three different tyrosine residues: Tyr239, Tyr240 and Tyr317 (4-6). GRB2/Sos binds to Shc phosphorylated at these sites, activating the Ras/Raf/MAPK pathway (4). Both Shc expression and its tyrosine phosphorylation play an essential and nonredundant role in thymic T cell development (7).
Caculated MW:   46,52,66 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:500
Reacitivity:   Human, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information