ARP7337-12 [Polyclonal Antibody]
UBE3A Rabbit Polyclonal Antibody
www.yhsbio.com
market@yhsbio.com
support@yhsbio.com
+86-21-54651191
Room 703,Building 6,333# Guiping
Rd.,Xuhui District,Shanghai,China
DATASHEET
Species:   Rabbit
Applications:   WB
Immunogen Range:   A synthetic peptide corresponding to human UBE3A
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   7337
Swiss Prot:   Q05086
Synonyms:   ANCR, AS, E6-AP, EPVE6AP, FLJ26981, HPVE6A
Purification:   Affinity purification
Storage:   Store at -20°C. For long term storage store at -80°C in PBS, pH 7.2 (30% glycerol, 0.5 mg/mL BSA, 0.01% thimerosal).Avoid freeze/thaw cycles.
Background:   This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined. [provided by RefSeq
Caculated MW:   98 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:500-1:2500
Reacitivity:   Human, Mouse
For research use only. Not intended for diagnostic or therapeutic use!
Additional information