ARP8140-11 [Polyclonal Antibody]
SLC7A5 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   IHC
Immunogen Range:   A synthetic peptide corresponding to human SLC7A5
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   8140
Swiss Prot:   Q01650
Synonyms:   4F2LC, CD98, D16S469E, E16, LAT1, MPE16, hLAT1
Purification:   Affinity purification
Storage:   Store at -20°C in PBS (0.1% proclin, 2.0% Block Ace).Avoid freeze/thaw cycles.
Background:   L-type amino acid transporter 1 (LAT1), also known as Solute carrier family 7 member 5 (SLC7A5), is a high-affinity neutral transporter of larger amino acids. It facilitates the cellular amino acid uptake in a sodium independent manner (1-2) and selectively transports D-and L-isomers of small neutral amino acids (3). LAT1 also regulates amino acid exchange in conjunction with solute carrier family 1 member 5 (SLC1A5) (2,4-6). Transport of thyroid hormones across the placenta is established via LAT1 during normal fetal development (7). LAT1 promotes neuronal cell proliferation by regulating the transport of amino acids across the blood brain barrier (8). LAT1 is upregulated in various cancer types including breast cancer, lung cancer, prostate cancer, and gliomas (9,10). High expression of LAT1 is detected in non-small cell lung cancer with lymph node metastases(9,11,12). Increased LAT1 expression is a novel biomarker of high grade malignancy in prostate cancers (12). Inhibition of LAT1 suppresses tumor cell growth in several tumor types (10,13).
Caculated MW:   39 kDa
Observed MW:   Refer to Figures
Applications:   IHC 5-10 ug/mL
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information