ARP5361-11 [Polyclonal Antibody]
PLXNA1 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB ELISA IP ICC
Immunogen Range:   A synthetic peptide corresponding to N-terminus half of semaphorin domain in human PLXNA1
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   5361
Swiss Prot:   Q9UIW2
Synonyms:   NOV, NOVP, PLEXIN-A1, PLXN1
Purification:   Affinity purification
Storage:   Store at -20°C in PBS (without Mg2+ and Ca2+), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide).Avoid freeze/thaw cycles.
Background:   Class 3 secreted semaphorin (Sema3A) is a chemorepellent that acts upon a wide variety of axons. As such, it induces a dramatic redistribution and depolymerization of actin filaments that results in growth cone collapse. Plexins are single membrane-spanning signaling proteins encompassing Plexin A1, A2, A3, and A4. Plexins form a complex with neuropilin-1 and -2 and the cell adhesion protein L1 to form a functional semaphorin receptor (1,2). The GTPase Rnd1 binds to the cytoplasmic domain of Plexin A1 to trigger cytoskeletal collapse. In contrast, the GTPase RhoD blocks Rnd1-mediated Plexin A1 activation and repulsion of sympathetic axons by Sema3A (3).
Caculated MW:   211 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:1000
IHC 1:100
Reacitivity:   Human, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information