ARP84446-11 [Polyclonal Antibody]
BRSK1 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB ELISA
Immunogen Range:   A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human BRSK1
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   84446
Swiss Prot:   Q8TDC3
Synonyms:   FLJ43009, KIAA1811
Purification:   Protein G purification
Storage:   Store at 4°C. For long term storage store at -20°C in PBS (0.09% sodium azide).Avoid freeze/thaw cycles.
Background:   Brain-specific kinase 1 (BRSK1; SAD-B) and Brain-specific kinase 2 (BRSK2; SAD-A) are serine/threonine kinases closely related to AMPK. LKB1 phosphorylates Thr189 in the T-loop of BRSK1 and Thr174 in the T-loop of BRSK2, resulting in activation of the kinases (1). BRSK1 localizes to synaptic vesicles in the hippocampus and cerebellum, together with the active zone proteins Bassoon and CAST, and BRSK1 phoshorylates the active zone protein RIM1 (2). An alternatively spliced from of BRSK1 displays unique activity during the cell cycle, phosphorylating Ser131 of γ-tubulin and controling centrosome duplication (3). Neuronal polarization, including axon formation, is fundamental for normal brain development. BRSK1 -/- and BRSK2 -/- mice have defects in neuronal polarity and impaired corticogenesis (4). Knockdown of BRSK1 and BRSK2 in vitro diminishes axonal growth (5).
Caculated MW:   90 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:100-1:500
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information