ARP5979-11 [Polyclonal Antibody]
RET Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB IHC ELISA
Immunogen Range:   A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human RET
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   5979
Swiss Prot:   P07949
Synonyms:   CDHF12, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET-ELE1, RET51
Purification:   Protein G purification
Storage:   Store at 4°C. For long term storage store at -20°C in PBS (0.09% sodium azide).Avoid freeze/thaw cycles.
Background:   This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed. [provided by RefSeq
Caculated MW:   170,175 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:100-1:500
IHC 1:50-1:100
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information