ARP389421-12 [Polyclonal Antibody]
LIN28B Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB ELISA FC
Immunogen Range:   A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human LIN28B
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   389421
Swiss Prot:   Q6ZN17
Synonyms:   CSDD2, FLJ16517
Purification:   Ammonium sulfate precipitation
Storage:   Store at 4°C. For long term storage store at -20°C in PBS (0.09% sodium azide).Avoid freeze/thaw cycles.
Background:   LIN28A and LIN28B are conserved, developmentally regulated RNA binding proteins that inhibit the processing and maturation of the let-7 family of miRNAs (1,2). The let-7 miRNAs have been implicated in repression of oncogenes such as Ras, Myc, and HMGA2 (3). It has recently been shown that upregulation of LIN28A and LIN28B in primary human tumors and human cancer cell lines is correlated with downregulation of let-7 miRNAs (4). LIN28 genes are reported to be involved in primordial germ cell development and germ cell malignancy (5). In addition, allelic variation in LIN28B is associated with regulating the timing of puberty in humans (6). Overexpression of LIN28A, in conjunction with Oct-4, Sox2, and Nanog, can reprogram human fibroblasts to pluripotent, ES-like cells (7).
Caculated MW:   31 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:50-1:100
FC 1:10-1:50
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information