ARP5923-11 [Polyclonal Antibody]
RASGRF1 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB IHC ELISA
Immunogen Range:   A synthetic peptide (conjugated with KLH) corresponding to residues surrounding S929 of human RASGRF1
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   5923
Swiss Prot:   Q13972
Synonyms:   CDC25, CDC25L, GNRP, GRF1, GRF55, H-GRF55, PP13187
Purification:   Protein A purification
Storage:   Store at 4°C. For long term storage store at -20°C in PBS (0.09% sodium azide).Avoid freeze/thaw cycles.
Background:   The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq
Caculated MW:   130 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:50-1:100
IHC 1:10-1:50
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information