ARP11177-11 [Polyclonal Antibody]
BAZ1A Rabbit Polyclonal Antibody
www.yhsbio.com
market@yhsbio.com
support@yhsbio.com
+86-21-54651191
Room 703,Building 6,333# Guiping
Rd.,Xuhui District,Shanghai,China
DATASHEET
Species:   Rabbit
Applications:   IHC
Immunogen Range:   A recombinant protein corresponding to amino acids of human BAZ1A
Clonality:   Polyclonal Antibody
Isotype:   IgG
GENE ID:   11177
Swiss Prot:   Q9NRL2
Synonyms:   ACF1, DKFZp586E0518, FLJ14383, WALp1, WCRF180, hACF1
Purification:   Antigen affinity purification
Storage:   Store at 4°C. For long term storage store at -20°C in PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).Avoid freeze/thaw cycles.
Background:   The mammalian imitation SWI (ISWI) complexes are characterized by two ATPase subunits: Snf2h and Snf2l (1). Snf2h interacts with ATP-utilizing chromatin assembly and remodeling factor 1 (ACF1) to comprise the ACF chromatin-remodeling complex (1). ACF1 (BAZ1A) has distinct roles in development (2), regulation of chromatin structure (3), and DNA damage response (4,5). Different developmental stages dictate the expression of ACF1 in Drosophila, and alterations in ACF1 expression during Drosophila development leads to deviation from normal chromatin organization (2). ACF1 functions in heterochromatin formation during development and is involved in the initial establishment of diversified chromatin structures. In vivo studies demonstrate that heterochromatin protein 1 (HP1) binding to methylated lysine 9 of histone H3 is enhanced by the interaction of ACF1 with chromatin (6). Chromatin-remodeling factors are required during DNA damage in order to allow signaling molecules and damaging enzymes to access the site (4). Depletion of hACF1 increases apoptosis and vulnerability to radiation and compromises G2/M arrest activated in response to X-ray and UV exposure (4). Depletion of ACF1 also sensitizes cells to DNA double-stranded breaks (DSBs) and impairs DNA repair (5). Specifically, accumulation of Ku at DSBs sites may depend on the presence of ACF1 (5).
Caculated MW:   203 kDa
Observed MW:   Refer to Figures
Applications:   IHC 1:50-1:200
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information