ARP11184-12 [Polyclonal Antibody]
MAP4K1 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB
Immunogen Range:   A synthetic peptide corresponding to human MAP4K1
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   11184
Swiss Prot:   Q92918
Synonyms:   HPK1
Purification:   Affinity chromatography
Storage:   Store at -20°C in PBS, pH 7.2 (0.05% sodium azide).Avoid freeze/thaw cycles.
Background:   Hematopoietic progenitor kinase 1(HPK1) is a member of the germinal center kinases that is predominantly expressed in hematopoietic cells. HPK1 is a key component linking T or B cell receptors to SAPK/JNK and IkappaB kinase pathways in lymphocytes (1-3). Through its proline-rich motif, HPK1 associates with multiple SH3 domain-containing adaptor proteins, including GRB2, Nck, Crk, SLP-76, and BLNK. Phosphorylation of Tyr379 by Syk is necessary for HPK1 association with BLNK and SLP-76, as well as for HPK1 activity (4,5). Caspase cleavage of HPK1 also modulates the the biological function of HPK1 (3,6,7).
Caculated MW:   97 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:500-1:1000
Reacitivity:   Human, Mouse
For research use only. Not intended for diagnostic or therapeutic use!
Additional information