ARP64855-15 [Polyclonal Antibody]
FAM129B Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB
Immunogen Range:   A synthetic peptide corresponding to residues surrounding S712 of human FAM129B
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   64855
Swiss Prot:   Q96TA1
Synonyms:   C9orf88, DKFZP434H0820, FLJ13518, FLJ22151, FLJ22298, MEG-3, OC58, bA356B19.6
Purification:   Affinity chromatography
Storage:   Store at -20°C in PBS (without Mg2+ and Ca2+), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide).Avoid freeze/thaw cycles.
Background:   FAM129B/Niban-like protein 1 (family with sequence similarity 129, member B) belongs to a poorly characterized family of Niban proteins that also includes FAM129A/Niban and FAM129C/Niban-like protein 2. FAM129A/Niban is implicated in the ER stress response and is upregulated at the protein level in thyroid carcinoma (1,2). FAM129C/Niban-like protein 2 is preferentially expressed in B-cells and is one of five biomarkers upregulated in whole blood from patients with colorectal carcinoma (3,4). FAM129B is broadly expressed and has been shown to be a downstream target of B-Raf in melanoma cells (5). Though FAM129B does not appear to regulate cell growth and division, phosphorylation of FAM129B by B-Raf is essential for the invasive potential of melanoma and non-melanoma cell lines (5). Deletion of FAM129B in melanoma cells significantly impairs B-Raf/MEK/Erk-dependent invasion into the extracellular matrix (5).
Caculated MW:   95 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:500-1:1000
Reacitivity:   Human, Mouse
For research use only. Not intended for diagnostic or therapeutic use!
Additional information