ARP8243-12 [Polyclonal Antibody]
SMC1A Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB IHC
Immunogen Range:   A synthetic peptide corresponding to residues surrounding S957 of human SMC1A
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   8243
Swiss Prot:   Q14683
Synonyms:   CDLS2, DKFZp686L19178, DXS423E, KIAA0178, MGC138332, SB1.8, SMC1, SMC1L1, SMC1alpha, SMCB
Purification:   Affinity chromatography
Storage:   Store at -20°C in PBS (without Mg2+ and Ca2+), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide).Avoid freeze/thaw cycles.
Background:   Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. [provided by RefSeq
Caculated MW:   145 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:500-1:1000
IHC 1:50-1:100
Reacitivity:   Human, Mouse
For research use only. Not intended for diagnostic or therapeutic use!
Additional information