ARP8323-11 [Polyclonal Antibody]
FZD6 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   IHC
Immunogen Range:   A synthetic peptide corresponding to 16 amino acid at N-terminus of human FZD6
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   8323
Swiss Prot:   O60353
Synonyms:   Hfz6
Purification:   Immunoaffinity chromatography
Storage:   Store at 4°C. For long term storage store at -20°C in PBS (0.1% sodium azide).Avoid freeze/thaw cycles.
Background:   This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq
Caculated MW:   75-85 kDa
Observed MW:   Refer to Figures
Applications:   IHC 6-14 ug/mL
Reacitivity:   Gorilla, Human, Monkey, Orangutan
For research use only. Not intended for diagnostic or therapeutic use!
Additional information