ARP2322P-12 [Polyclonal Antibody]
Phospho-FLT3-Tyr591 Rabbit Polyclonal Antibody
www.yhsbio.com
market@yhsbio.com
support@yhsbio.com
+86-21-54651191
Room 703,Building 6,333# Guiping
Rd.,Xuhui District,Shanghai,China
DATASHEET
Species:   Rabbit
Applications:   IHC
Immunogen Range:   A synthetic phosphopeptide corresponding to residues surrounding Y591 of FLT3
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   2322
Swiss Prot:   P36888
Synonyms:   CD135, FLK2, STK1
Purification:   Ammonium sulfate precipitation
Storage:   Store at 4°C. For long term storage store at -20°C in PBS, pH 7.2 (0.05% sodium azide).Avoid freeze/thaw cycles.
Background:   This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq
Caculated MW:   130 kDa
Observed MW:   Refer to Figures
Applications:   IHC 1:50-1:200
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information