ARP57698-11 [Polyclonal Antibody]
KIAA1598 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB IHC
Immunogen Range:   A recombinant protein corresponding to amino acids of human KIAA1598
Clonality:   Polyclonal Antibody
Isotype:   IgG
GENE ID:   57698
Swiss Prot:   A0MZ66
Synonyms:   DKFZp686A0439, MGC40476, shootin-1
Purification:   Antigen affinity purification
Storage:   Store at 4°C. For long term storage store at -20°C in PBS, pH 7.5 (40% glycerol, 0.02% sodium azide).Avoid freeze/thaw cycles.
Background:   The differentiation process of neurons can be divided into five stages, each stage characterized by morphological changes observed in the developing cells. In stage 1, the cells extend lamellipodia and in stage 2 their lamellipodia develop into immature neurites. In stage 3 one neurite elongates rapidly to form an axon and in stage 4 the remaining immature neuritis elongate to form dendrites. In stage 5 synaptic contacts are formed and a neuronal network is established (1).Shootin1 is involved in generating internal asymmetric signals required for neuronal during stages 2 and 3. The extension of an axon requires considerable reorganization of the cytoskeleton mediated by PI3K/Akt and PI3K/Cdc42 signaling (1). Shootin1 is involved in regulating the subcellular localization of PI3 kinase. Furthermore, shootin1 is upregulated during polarization and accumulates asymmetrically in a single neurite that consequently elongates rapidly to form an axon (2).
Caculated MW:   60 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:250-1:500
IHC 1:2500-1:5000
Reacitivity:   Human, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information