ARP5063-11 [Polyclonal Antibody]
PAK3 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB IHC ELISA
Immunogen Range:   A synthetic peptide (conjugated with KLH) corresponding to internal region of human PAK3
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   5063
Swiss Prot:   O75914
Synonyms:   CDKN1A, MRX30, MRX47, OPHN3, PAK3beta, bPAK, hPAK3
Purification:   Protein G purification
Storage:   Store at 4°C. For long term storage store at -20°C in PBS (0.09% sodium azide).Avoid freeze/thaw cycles.
Background:   PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The protein encoded by this gene forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of non-syndromic mental retardation X-linked type 30 (MRX30), also called X-linked mental retardation type 47 (MRX47). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq
Caculated MW:   65 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:50-1:100
IHC 1:50-1:100
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information