ARP6510-12 [Polyclonal Antibody]
SLC1A5 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   IHC IF
Immunogen Range:   A recombinant protein corresponding to amino acids of human SLC1A5
Clonality:   Polyclonal Antibody
Isotype:   IgG
GENE ID:   6510
Swiss Prot:   Q15758
Synonyms:   AAAT, ASCT2, ATBO, FLJ31068, M7V1, M7VS1, R16, RDRC
Purification:   Antigen affinity purification
Storage:   Store at 4°C. For long term storage store at -20°C in PBS, pH 7.5 (40% glycerol, 0.02% sodium azide).Avoid freeze/thaw cycles.
Background:   Sodium-dependent neutral amino acid transporter type 2 (ASCT2 or SLC1A5) is a neutral amino acid transporter that regulates the uptake of essential amino acids in conjunction with the SLC7A5 bilateral transporter (1,2). ASCT2 appears to be the major glutamine transporter in hepatoma cells and is thought to provide essential amino acids needed for tumor growth (3). Additional evidence suggests that ASCT2 plays a role in activating mTORC1 signaling and is required to suppress autophagy (4,5). Cell surface ASCT2 serves as a receptor for several mammalian interference retroviruses associated with cases of infectious immunodeficiency; variation in a small region of an extracellular loop (ECL2) may be responsible for species-specific differences in receptor function (6).
Caculated MW:   49,75 kDa
Observed MW:   Refer to Figures
Applications:   IHC 1:50-1:200
IF 1-4 ug/mL
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information