ARP91584-11 [Polyclonal Antibody]
PLXNA4 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   IHC
Immunogen Range:   A recombinant protein corresponding to amino acids of human PLXNA4
Clonality:   Polyclonal Antibody
Isotype:   IgG
GENE ID:   91584
Swiss Prot:   Q9HCM2
Synonyms:   DKFZp434G0625, DKFZp566O0546, FAYV2820, FLJ35026, FLJ38287, KIAA1550, PLEXA4, PLXNA4A, PLXNA4B, PRO34003
Purification:   Antigen affinity purification
Storage:   Store at 4°C. For long term storage store at -20°C in PBS, pH 7.5 (40% glycerol, 0.02% sodium azide).Avoid freeze/thaw cycles.
Background:   Class 3 secreted semaphorin (Sema3A) is a chemorepellent that acts upon a wide variety of axons. As such, it induces a dramatic redistribution and depolymerization of actin filaments that results in growth cone collapse. Plexins are single membrane-spanning signaling proteins encompassing Plexin A1, A2, A3, and A4. Plexins form a complex with neuropilin-1 and -2 and the cell adhesion protein L1 to form a functional semaphorin receptor (1,2). The GTPase Rnd1 binds to the cytoplasmic domain of Plexin A1 to trigger cytoskeletal collapse. In contrast, the GTPase RhoD blocks Rnd1-mediated Plexin A1 activation and repulsion of sympathetic axons by Sema3A (3).
Caculated MW:   212 kDa
Observed MW:   Refer to Figures
Applications:   IHC 1:50-1:200
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information