ARP64855-11 [Polyclonal Antibody]
FAM129B Rabbit Polyclonal Antibody
www.yhsbio.com
market@yhsbio.com
support@yhsbio.com
+86-21-54651191
Room 703,Building 6,333# Guiping
Rd.,Xuhui District,Shanghai,China
DATASHEET
Species:   Rabbit
Applications:   WB IHC
Immunogen Range:   A recombinant protein corresponding to amino acids of human FAM129B
Clonality:   Polyclonal Antibody
Isotype:   IgG
GENE ID:   64855
Swiss Prot:   Q96TA1
Synonyms:   C9orf88, DKFZP434H0820, FLJ13518, FLJ22151, FLJ22298, MEG-3, OC58, bA356B19.6
Purification:   Antigen affinity purification
Storage:   Store at 4°C. For long term storage store at -20°C in PBS, pH 7.5 (40% glycerol, 0.02% sodium azide).Avoid freeze/thaw cycles.
Background:   FAM129B/Niban-like protein 1 (family with sequence similarity 129, member B) belongs to a poorly characterized family of Niban proteins that also includes FAM129A/Niban and FAM129C/Niban-like protein 2. FAM129A/Niban is implicated in the ER stress response and is upregulated at the protein level in thyroid carcinoma (1,2). FAM129C/Niban-like protein 2 is preferentially expressed in B-cells and is one of five biomarkers upregulated in whole blood from patients with colorectal carcinoma (3,4). FAM129B is broadly expressed and has been shown to be a downstream target of B-Raf in melanoma cells (5). Though FAM129B does not appear to regulate cell growth and division, phosphorylation of FAM129B by B-Raf is essential for the invasive potential of melanoma and non-melanoma cell lines (5). Deletion of FAM129B in melanoma cells significantly impairs B-Raf/MEK/Erk-dependent invasion into the extracellular matrix (5).
Caculated MW:   95 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:250-1:500
IHC 1:200-1:500
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information