ARP1124-12 [Polyclonal Antibody]
CHN2 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   IHC
Immunogen Range:   A recombinant protein corresponding to amino acids of human CHN2
Clonality:   Polyclonal Antibody
Isotype:   IgG
GENE ID:   1124
Swiss Prot:   P52757
Synonyms:   ARHGAP3, BCH, MGC138360, RHOGAP3
Purification:   Antigen affinity purification
Storage:   Store at 4°C. For long term storage store at -20°C in PBS (0.09% sodium azide).Avoid freeze/thaw cycles.
Background:   This gene is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain and an SH2 domain. This protein has GTPase-activating protein activity that is regulated by phospholipid binding and binding of diacylglycerol (DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane. The protein plays a role in the proliferation and migration of smooth muscle cells. Decreased expression of this gene is associated with high-grade gliomas and breast tumors, and increased expression of this gene is associated with lymphomas. Mutations in this gene have been associated with schizophrenia in men. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq
Caculated MW:   47 kDa
Observed MW:   Refer to Figures
Applications:   IHC 1:20-1:50
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information