ARP29881-11
[Polyclonal Antibody]
NPC1L1 Rabbit Polyclonal Antibody
www.yhsbio.com
market@yhsbio.com
support@yhsbio.com
+86-21-54651191
Room 703,Building 6,333# Guiping
Rd.,Xuhui District,Shanghai,China
market@yhsbio.com
support@yhsbio.com
+86-21-54651191
Room 703,Building 6,333# Guiping
Rd.,Xuhui District,Shanghai,China
DATASHEET
| Species: | Rabbit |
| Applications: | IHC |
| Immunogen Range: | A recombinant protein corresponding to amino acids of human NPC1L1 |
| Clonality: | Polyclonal Antibody |
| Isotype: | IgG |
| GENE ID: | 29881 |
| Swiss Prot: | Q9UHC9 |
| Synonyms: | / |
| Purification: | Antigen affinity purification |
| Storage: | Store at 4°C. For long term storage store at -20°C in PBS, pH 7.5 (40% glycerol, 0.02% sodium azide).Avoid freeze/thaw cycles. |
| Background: | Niemann-Pick C1-like 1 (NPC1L1) is a transmembrane protein that plays a critical role in cholesterol absorption (1). It is highly expressed in small intestine and localized along the brush border in both human and mouse epithelial cells (2,3). NPC1L1 mediates cholesterol uptake via vesicular endocytosis (4). Ezetimibe, a potent cholesterol absorption inhibitor used to treat hypercholesterolemia (5), inhibits cholesterol uptake by preventing NPC1L1 from incorporating into clathrin-coated vesicles (4). |
| Caculated MW: | 140 kDa |
| Observed MW: | Refer to Figures |
| Applications: |
IHC 1:20-1:50 |
| Reacitivity: | Human |
For research use only. Not intended for diagnostic or therapeutic use!
Additional information