AGP200186-12 [Polyclonal Antibody]
CRTC2 Goat Polyclonal Antibody
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Species:   Rabbit
Applications:   WB ELISA
Immunogen Range:   A synthetic peptide corresponding to amino acids 83-96 at internal region of human CRTC2
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   200186
Swiss Prot:   Q53ET0
Synonyms:   RP11-422P24.6, TORC2
Purification:   Antigen affinity purification
Storage:   Store at -20°C in Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide).Avoid freeze/thaw cycles.
Background:   Glucose homeostasis is regulated by hormones and cellular energy status. Elevations of blood glucose during feeding stimulate insulin release from pancreatic β-cells through a glucose sensing pathway. Feeding also stimulates release of gut hormones such as glucagon-like peptide-1 (GLP-1), which further induces insulin release, inhibits glucagon release and promotes β-cell viability. CREB-dependent transcription likely plays a role in both glucose sensing and GLP-1 signaling (1). The protein CRTC2 (CREB-regulated transcription coactivator 2)/TORC2 (transducer of regulated CREB activity 2) functions as a CREB co-activator (2,3) and is implicated in mediating the effects of these two pathways (4). In quiescent cells, CRTC2/TORC2 is phosphorylated at Ser171 and becomes sequestered in the cytoplasm via an interaction with 14-3-3 proteins. Glucose and gut hormones lead to the dephosphorylation of CRTC2/TORC2 and its dissociation from 14-3-3 proteins. Dephosphorylated CRTC2/TORC2 enters the nucleus to promote CREB-dependent transcription. CRTC2/TORC2 plays a key role in the regulation of hepatic gluconeogenic gene transcription in response to hormonal and energy signals during fasting (5).
Caculated MW:   80 kDa
Observed MW:   Refer to Figures
Applications:   WB 0.3-1 ug/mL
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information