ARP51330-13 [Polyclonal Antibody]
TNFRSF12A Rabbit Polyclonal Antibody
www.yhsbio.com
market@yhsbio.com
support@yhsbio.com
+86-21-54651191
Room 703,Building 6,333# Guiping
Rd.,Xuhui District,Shanghai,China
DATASHEET
Species:   Rabbit
Applications:   IHC
Immunogen Range:   A synthetic peptide corresponding to internal region of human TNFRSF12A
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   51330
Swiss Prot:   Q9NP84
Synonyms:   CD266, FN14, TWEAKR
Purification:   Immunoaffinity purification
Storage:   Store at 4°C in PBS, pH 7.6 (1% BSA, 0.1% sodium azide). Do not freeze.
Background:   The receptor for TWEAK, fibroblast growth factor-inducible 14 (Fn14), is a member of the TNF superfamily of receptors thought to be involved in cell growth, adhesion and migration (1). Its expression is regulated by a number of different growth factors (1,2). Elevated expression is also seen in some cancers including hepatocellular carcinomas (3), glioblastomas (4), and pancreatic cancer (5). The receptor contains a binding site for members of the TNFR-associated factor (TRAF) family that promotes the activation of NF-κB (1,6). Recent studies have suggeted some therapeutic potential of TWEAK and its receptor signaling in regards to autoimmunity and cancer treatment (7-9).
Caculated MW:   14-17 kDa
Observed MW:   Refer to Figures
Applications:   IHC 1:100
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information