ARP5664-11
[Polyclonal Antibody]
PSEN2 Rabbit Polyclonal Antibody
www.yhsbio.com
market@yhsbio.com
support@yhsbio.com
+86-21-54651191
Room 703,Building 6,333# Guiping
Rd.,Xuhui District,Shanghai,China
market@yhsbio.com
support@yhsbio.com
+86-21-54651191
Room 703,Building 6,333# Guiping
Rd.,Xuhui District,Shanghai,China
DATASHEET
| Species: | Rabbit |
| Applications: | WB IHC |
| Immunogen Range: | A synthetic peptide corresponding to internal region of human PSEN2 |
| Clonality: | Polyclonal Antibody |
| Isotype: | / |
| GENE ID: | 5664 |
| Swiss Prot: | P49810 |
| Synonyms: | AD3L, AD4, PS2, STM2 |
| Purification: | Affinity purification |
| Storage: | Store at -20°C on dry atmosphere.After reconstitution with 200 uL of deionized water and concentration will be 500 ug/mL, store at -20°C or lower. |
| Background: | Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq |
| Caculated MW: | 23 kDa |
| Observed MW: | Refer to Figures |
| Applications: |
WB 1 ug/mL IHC 1 ug/mL |
| Reacitivity: | Human, Rat |
For research use only. Not intended for diagnostic or therapeutic use!
Additional information