ARP51530-11 [Polyclonal Antibody]
ZC3HC1 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB ELISA IF
Immunogen Range:   A synthetic peptide corresponding to residues surrounding S354 of human ZC3HC1
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   51530
Swiss Prot:   Q86WB0
Synonyms:   1110054L24Rik, HSPC216, NIPA
Purification:   Affinity purification
Storage:   Store at -20°C in PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide).Avoid freeze/thaw cycles.
Background:   NIPA (nuclear interaction partner of ALK) is an F-box-containing protein that is an essential component of the SCF-type E3 ligase (SCFNIPA) complex, a complex that controls the completion of S-phase and mitotic entry (1). This control is mediated by the ubiquitination and subsequent degradation of cell cycle regulatory proteins, whose oscillation of protein levels is required for proper cell cycle progression (2).Expression levels of NIPA are low in G0/G1 phases and upregulated in S and G2/M phases. The SCFNIPA complex targets nuclear cyclin B1 for ubiquitination in interphase, whereas phosphorylation of NIPA in late G2 phase and mitosis inactivates the complex to allow for accumulation of cyclin B1 (3). NIPA may have an anti-apoptotic role in NPM-ALK-mediated signaling events (4).
Caculated MW:   60-65 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:500-1:1000
IF 1:500-1:1000
Reacitivity:   Human, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information