ARP321-11 [Polyclonal Antibody]
APBA2 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   IHC ELISA
Immunogen Range:   A synthetic peptide corresponding to internal of human APBA2
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   321
Swiss Prot:   Q99767
Synonyms:   FLJ25458, FLJ37160, GIDRP86, PSORT
Purification:   Affinity purification
Storage:   Store at -20°C in PBS, pH 7.4 (150mM NaCl, 0.02% sodium azide, 50% glycerol).Avoid freeze/thaw cycles.
Background:   Amyloid β A4 precursor protein-binding family A member 2 (APBA2) is a neuronal adaptor protein that interacts with the amyloid β precursor protein (APP) (1). The amyloid β-protein (Aβ) is the principal component of amyloid plaques, a pathological hallmark of Alzheimer’s disease (2). APBA2 has been shown to stabilize APP metabolism and suppress the secretion of Aβ (3). APBA2 mediates interaction between APP and the neural type I membrane protein Alcadein (Alc) by linking their cytoplasmic domains, thereby forming a tripartite complex of the three proteins in neurons (4).
Caculated MW:   135 kDa
Observed MW:   Refer to Figures
Applications:   IHC 1:50-1:100
Reacitivity:   Human, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information