ARP57534-11 [Polyclonal Antibody]
MIB1 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB IHC ELISA IF
Immunogen Range:   A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human MIB1
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   57534
Swiss Prot:   Q86YT6
Synonyms:   DIP-1, DKFZp686I0769, DKFZp761M1710, FLJ90676, MGC129659, MGC129660, MIB, ZZANK2, ZZZ6
Purification:   Affinity purification
Storage:   Store at 4°C. For long term storage store at -20°C in PBS (0.09% sodium azide).Avoid freeze/thaw cycles.
Background:   Mindbomb homolog 1 (MIB1) is an E3 ligase that facilitates the ubiquitination and the subsequent endocytosis of the Notch ligands, Delta and Jagged (1,2). MIB1 appears to promote the ubiquitination and degradation of death-associated protein kinase (DAPK1) in vitro (3). Expression of MIB1 is seen in both adult and embryonic murine tissues (4). Recently, MIB1 was reported to regulate the extrinsic cell death pathway by binding to cellular FLICE-like inhibitory proteins (cFLIP-L and cFLIP-S), which reduces the interaction of caspase-8 with cFLIP and leads to cell death (5). MIB1 is also involved in T and marginal zone B (MZB) cell development in the lymphopoietic niches (6).
Caculated MW:   110 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:100-1:500
IHC 1:50-1:100
IF 1:20-1:100
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information