ARP51330-12 [Polyclonal Antibody]
TNFRSF12A Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB
Immunogen Range:   A recombinant Fc fusion protein corresponding to human TNFRSF12A
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   51330
Swiss Prot:   Q9NP84
Synonyms:   CD266, FN14, TWEAKR
Purification:   Affinity purification
Storage:   Store at 4°C for three months. For long term storage store at -20°C in PBS (0.02% sodium azide).Avoid freeze/thaw cycles.
Background:   The receptor for TWEAK, fibroblast growth factor-inducible 14 (Fn14), is a member of the TNF superfamily of receptors thought to be involved in cell growth, adhesion and migration (1). Its expression is regulated by a number of different growth factors (1,2). Elevated expression is also seen in some cancers including hepatocellular carcinomas (3), glioblastomas (4), and pancreatic cancer (5). The receptor contains a binding site for members of the TNFR-associated factor (TRAF) family that promotes the activation of NF-κB (1,6). Recent studies have suggeted some therapeutic potential of TWEAK and its receptor signaling in regards to autoimmunity and cancer treatment (7-9).
Caculated MW:   14-17 kDa
Observed MW:   Refer to Figures
Applications:   WB 1 ug/mL
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information