AGPM002N-11 [Polyclonal Antibody]
Nitro-Tyrosine Goat Polyclonal Antibody
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Species:   Goat
Applications:   WB ELISA
Immunogen Range:   Nitrotyrosine conjugated with KLH
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   /
Swiss Prot:   /
Synonyms:   /
Purification:   Affinity purification
Storage:   Store at 4°C. For long term storage store at -20°C n 75 mM PBS, 75 mM NaCl, 0.5 mM EDTA, pH 7.2 (0.02% sodium azide).Avoid freeze/thaw cycles.
Background:   Nitric oxide (NO) is implicated in carcinogenesis (1), chronic infection, inflammation (2) and neurodegeneration (3). High levels of both superoxide and nitric oxide in tissues interact to form peroxynitrite, a potent oxidant that can modify Tyr residues in proteins to form 3-nitro-tyrosine (4). Tyrosine nitration of mitochondrial manganese superoxide dismutase results in loss of enzymatic activity (4). The nitration of p53 at Tyr residues abolishes its capacity for binding to its DNA consensus sequence (5).
Caculated MW:   /
Observed MW:   Refer to Figures
Applications:   WB 1:5000-1:40000
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information