ARP1387-11 [Polyclonal Antibody]
CREBBP Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   IHC
Immunogen Range:   A synthetic peptide corresponding to amino acids 2422-2441 of human CREBBP
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   1387
Swiss Prot:   Q92793
Synonyms:   CBP, KAT3A, RSTS
Purification:   Immunoaffinity purification
Storage:   Store at 4°C in 10 mM PBS, pH 7.4 (1% BSA, 0.1% sodium azide).
Background:   This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq
Caculated MW:   300 kDa
Observed MW:   Refer to Figures
Applications:   IHC 1:100
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information