ARP5970P-11 [Polyclonal Antibody]
Phospho-RELA-Ser276 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB ELISA
Immunogen Range:   A synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S276 of human RELA
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   5970
Swiss Prot:   Q04206
Synonyms:   MGC131774, NFKB3, p65
Purification:   Affinity purification
Storage:   Store at 4°C. For long term storage store at -20°C in antiserum (0.1% sodium azide).Avoid freeze/thaw cycles.
Background:   NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA, or RELB (MIM 604758) to form the NFKB complex. The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of NFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008 or NFKBIB, MIM 604495), which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM
Caculated MW:   65-80 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:1000
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information