ARP22985-11 [Polyclonal Antibody]
ACIN1 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB
Immunogen Range:   A synthetic peptide corresponding to N-terminus of human ACIN1
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   22985
Swiss Prot:   Q9UKV3
Synonyms:   ACINUS, ACN, DKFZp667N107, KIAA0670, fSAP152
Purification:   Affinity purification
Storage:   Store at 4°C. For long term storage store at -20°C n PBS (0.02% sodium azide).Avoid freeze/thaw cycles.
Background:   Acinus (apoptotic chromatin condensation inducer in the nucleus) is a caspase substrate that has been implicated in nuclear changes during apoptosis (1). Chromatin condensation and DNA fragmentation are both nuclear morphological features associated with apoptosis. Acinus is expressed in different isoforms (L, S, S') most likely generated by alternative splicing (1). During apoptosis Acinus is cleaved by caspase-3 to generate a 23 kDa fragment that was reported to induce chromatin condensation (1). Acinus has been identified to be a component of the spliceosome complex, ASAP, suggesting a role in pre-mRNA processing (2-4). Down regulation of Acinus by RNA interference inhibits cell growth (5). This study also found that loss of Acinus inhibits DNA fragmentation but not chromatin condensation during apoptosis.
Caculated MW:   84,83,220 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:500-1:1000
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information