ARP4659-11 [Polyclonal Antibody]
PPP1R12A Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB ELISA
Immunogen Range:   A synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding T853 of human MBS/MYPT1
Clonality:   Polyclonal Antibody
Isotype:   IgG1
GENE ID:   4659
Swiss Prot:   O14974
Synonyms:   MBS, MGC133042, MYPT1
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM HEPES/KOH, 150 mM NaCl, pH 7.5 (50% glycerol).Avoid freeze/thaw cycles.
Background:   Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Caculated MW:   140 kDa
Observed MW:   Refer to Figures
Applications:   WB 0.4-1 ug/mL
Reacitivity:   Chiken, Human, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information