AMM5797-11 [Monoclonal Antibody]
PTPRM Rabbit Monoclonal Antibody
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Species:   Mouse
Applications:   WB IP
Immunogen Range:   A recombinant protein corresponding to human PTPRM
Clonality:   Monoclonal Antibody
Isotype:   IgG1 Kappa
GENE ID:   5797
Swiss Prot:   P28827
Synonyms:   MGC166994, PTPRL1, R-PTP-MU, RPTPM, RPTPU, hR-PTPu
Purification:   Affinity purification
Storage:   Store at -20°C in PBS, pH 7.4 (50% glycerol, 0.09% sodium azide).Avoid freeze/thaw cycles.
Background:   The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms. [provided by RefSeq
Caculated MW:   100,110,210 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:1000
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information