AMM6774-11 [Monoclonal Antibody]
STAT3 Mouse Monoclonal Antibody
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Species:   Mouse
Applications:   WB
Immunogen Range:   A recombinant protein corresponding to amino acids 1-170 of human STAT3
Clonality:   Monoclonal Antibody
Isotype:   IgG1
GENE ID:   6774
Swiss Prot:   P40763
Synonyms:   APRF, FLJ20882, HIES, MGC16063
Purification:   Affinity purification
Storage:   Store at -20°C in PBS, pH 7.3 (1% BSA, 0.08% sodium azide).Avoid freeze/thaw cycles.
Background:   The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq
Caculated MW:   79.86 kDa
Observed MW:   Refer to Figures
Applications:   WB 0.5-1 ug/mL
Reacitivity:   Human, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information