AMM920-14
[Monoclonal Antibody]
CD4 Mouse Monoclonal Antibody
www.yhsbio.com
market@yhsbio.com
support@yhsbio.com
+86-21-54651191
Room 703,Building 6,333# Guiping
Rd.,Xuhui District,Shanghai,China
market@yhsbio.com
support@yhsbio.com
+86-21-54651191
Room 703,Building 6,333# Guiping
Rd.,Xuhui District,Shanghai,China
DATASHEET
| Species: | Mouse |
| Applications: | IHC |
| Immunogen Range: | A recombinant protein corresponding to human T-cell CEM cells of human CD4 |
| Clonality: | Monoclonal Antibody |
| Isotype: | IgG1 |
| GENE ID: | 920 |
| Swiss Prot: | P01730 |
| Synonyms: | CD4mut |
| Purification: | Affinity purification |
| Storage: | Store at -20°C on dry atmosphere.After reconstitution with 1 mL of 1.2% sodium acetate or neutral PBS and concentration will be 100 ug/mL, store at -20°C or lower.Avoid freeze/thaw cycles. |
| Background: | Cluster of Differentiation 4 (CD4) is a glycoprotein composed of an amino-terminal extracellular domain (four domains: D1-D4 with Ig-like structures), a transmembrane part and a short cytoplasmic tail. CD4 is expressed on the surface of T helper cells, regulatory T cells, monocytes, macrophages and dendritic cells, and plays an important role in the development and activation of T cells. On T cells, CD4 is the co-receptor for the T cell receptor (TCR), and these two distinct structures recognize the Antigen–Major Histocompatibility Complex (MHC). Specifically, the D1 domain of CD4 interacts with the β2-domain of the MHC class II molecule. CD4 ensures specificity of the TCR–antigen interaction, prolongs the contact between the T cell and the antigen presenting cell and recruits the tyrosine kinase Lck, which is essential for T cell activation (1). |
| Caculated MW: | 55 kDa |
| Observed MW: | Refer to Figures |
| Applications: |
IHC 1 ug/mL |
| Reacitivity: | Human, Rat |
For research use only. Not intended for diagnostic or therapeutic use!
Additional information