
| Species: | Mouse |
| Applications: | WB IHC ELISA IF FC |
| Immunogen Range: | A recombinant protein corresponding to human NEFL |
| Clonality: | Monoclonal Antibody |
| Isotype: | IgG1 |
| GENE ID: | 4747 |
| Swiss Prot: | P07196 |
| Synonyms: | CMT1F, CMT2E, FLJ53642, NF-L, NF68, NFL |
| Purification: | Affinity purification |
| Storage: | Store at 4°C. For long term storage store at -20°C in PBS (0.5% protein stabilizer, 0.05% sodium azide). Avoid freeze/thaw cycles. |
| Background: | Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. [provided by RefSeq |
| Caculated MW: | 70 kDa |
| Observed MW: | Refer to Figures |
| Applications: |
WB 1:500-1:2000 IHC 1:200-1:1000 IF 1:200-1:1000 FC 1:200-1:400 |
| Reacitivity: | Human |