ARP5894P-31 [Polyclonal Antibody]
Phospho-RAF1-Ser296 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   ELISA Dot
Immunogen Range:   A synthetic phosphopeptide corresponding to residues surrounding Ser296 of human c-Raf
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   5894
Swiss Prot:   P04049
Synonyms:   NS5, CRAF, Raf-1, c-Raf
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Background:   This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
Caculated MW:   74 kDa
Observed MW:   Refer to Figures
Applications:  
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information