ARP837-14 [Polyclonal Antibody]
CASP4 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB IHC
Immunogen Range:   A synthetic peptide corresponding to N-terminus of human CASP4
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   837
Swiss Prot:   P49662
Synonyms:   ICE(rel)II, ICEREL-II, ICH-2, Mih1/TX, TX
Purification:   Affinity purification
Storage:   Store at -20°C in PBS (0.02% sodium azide).Avoid freeze/thaw cycles.
Background:   This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq
Caculated MW:   45 kDa
Observed MW:   Refer to Figures
Applications:   WB 1 ug/mL
Reacitivity:   Human, Mouse
For research use only. Not intended for diagnostic or therapeutic use!
Additional information