ARP1808-11 [Polyclonal Antibody]
DPYSL2 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB ELISA
Immunogen Range:   A synthetic peptide corresponding to C-terminus of human DPYSL2
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   1808
Swiss Prot:   Q16555
Synonyms:   CRMP2, DHPRP2, DRP-2, DRP2
Purification:   Affinity purification
Storage:   Store at -20°C in PBS, pH 7.2 (50% glycerol, 0.01% sodium azide).Avoid freeze/thaw cycles.
Background:   Collapsin Response Mediator Protein-2 (CRMP-2) is expressed at high levels in the developing nervous system and plays a critical role in axonal outgrowth by specifying axon/dendrite fate and establishing neuronal polarity (1,2). CRMP-2 enhances axon elongation and branching by binding to tubulin heterodimers to promote microtubule assembly (3). GSK-3β inactivates CRMP-2 by phosphorylating it at Thr514. CRMP-2 is primed following phosphorylation at Ser522 by CDK5 and at Thr518 by GSK-3β (2). Phosphorylation of CRMP-2, which decreases tubulin binding ability, can be inhibited by NT-3 and BDNF through the PI3 kinase/Akt pathway (2). CRMP-2 also mediates semaphorin-induced growth cone collapse (4). Hyperphosphorylation of CRMP-2 and is found in Alzheimer disease plaques with concurrent elevated GSK-3β activity in these patients (5).
Caculated MW:   55-65 kDa
Observed MW:   Refer to Figures
Applications:  
Reacitivity:   Human, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information