ARP10551-13 [Polyclonal Antibody]
AGR2 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB IHC ELISA IF
Immunogen Range:   A synthetic peptide corresponding to 17 amino acids at N-terminus of human AGR2
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   10551
Swiss Prot:   O95994
Synonyms:   AG2, GOB-4, HAG-2, XAG-2
Purification:   Peptide affinity purification
Storage:   Store at 4°C. For long term storage store at -20°C in PBS (0.02% sodium azide).Avoid freeze/thaw cycles.
Background:   Anterior gradient homolog 2 (AGR2) is a member of the protein disulfide isomerase (PDI) family of proteins and a homolog of the Xenopus laevis cement gland protein (1). In normal human tissues, AGR2 is expressed most abundantly in intestinal cells. Research studies have found AGR2 is overexpressed in a number of adenocarcinomas, including those derived from breast, pancreas, ovary, prostate and esophagus (2-4). In vitro and in vivo studies have shown that AGR2 positively regulates cell growth and division, while its overexpression can promote cell transformation (5,6). The latter functions of AGR2 were shown to involve YAP1-mediated up-regulation of amphiregulin expression, implicating AGR2 in both the EGF and Hippo kinase signaling pathways (6).
Caculated MW:   18 kDa
Observed MW:   Refer to Figures
Applications:   WB 1-2 ug/mL
IHC 5 ug/mL
IF 20 ug/mL
Reacitivity:   Human, Mouse
For research use only. Not intended for diagnostic or therapeutic use!
Additional information