ARP6786-11 [Polyclonal Antibody]
STIM1 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB IF ICC
Immunogen Range:   A synthetic peptide corresponding to amino acids 600-685 of human STIM1
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   6786
Swiss Prot:   Q13586
Synonyms:   STIM1
Purification:   Affinity purification
Storage:   Store at -20°C or -80°C in PBS (30% glycerol, 0.1% sodium azide).Avoid freeze/thaw cycles.
Background:   This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene
Caculated MW:   85 kDa
Observed MW:   Refer to Figures
Applications:   IF 1:50-1:200
ICC 1:50-1:200
Reacitivity:   Bovine, Dog, Human, Mouse, Pig, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information