ARP25937-11 [Polyclonal Antibody]
WWTR1 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB IHC IP IF
Immunogen Range:   A synthetic peptide corresponding to human WWTR1
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   25937
Swiss Prot:   Q9GZV5
Synonyms:   DKFZp586I1419, TAZ
Purification:   Affinity purification
Storage:   Store at -20°C or -80°C in PBS (10% glycerol, 0.02% sodium azide).Avoid freeze/thaw cycles.
Background:   CBP (CREB-binding protein) and p300 are highly conserved and functionally related transcriptional co-activators that associate with transcriptional regulators and signaling molecules, integrating multiple signal transduction pathways with the transcriptional machinery (1,2). CBP/p300 also contain histone acetyltransferase (HAT) activity, allowing them to acetylate histones and other proteins (2). Phosphorylation of p300 at Ser89 by PKC represses its transciptional acitivity, and phosphorylation at the same site by AMPK disrupts the association of p300 with nuclear receptors (3,4). Ser1834 phosphorylation of p300 by Akt disrupts its association with C/EBPβ (5). Growth factors induce phosphorylation of CBP at Ser437, which is required for CBP recruitment to the transcription complex (6). CaM kinase IV phosphorylates CBP at Ser302, which is required for CBP-dependent transcriptional activation in the CNS (7). The role of acetylation of CBP/p300 is of particular interest (2,8). Acetylation of p300 at Lys1499 has been demonstrated to enhance its HAT activity and affect a wide variety of signaling events (9).
Caculated MW:   50 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:1000-1:5000
IF 1:50-1:200
ICC 1:50-1:200
Reacitivity:   Human, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information